Intra-cochlear Flushing Reduces Tissue Response to Cochlear Implantation

Tayla Razmovski; Kate M Brody; Dimitra Stathopoulos; Dongcheng Zhang; Ellie Cho; Amy J Hampson; Aaron Collins; Christofer Bester; Stephen O'Leary

Journal article

Intra-cochlear Flushing Reduces Tissue Response to Cochlear Implantation

Tayla Razmovski, Kate M Brody, Dimitra Stathopoulos, Dongcheng Zhang, Ellie Cho, Amy J Hampson, Aaron Collins, Christofer Bester, Stephen O'Leary

The Laryngoscope | Wiley | Published : 2024

DOI: 10.1002/lary.31022

Open access

Abstract

Introduction: Intraoperative trauma leading to bleeding during cochlear implantation negatively impacts residual hearing of cochlear implant recipients. There are no clinical protocols for the removal of blood during implantation, to reduce the consequential effects such as inflammation and fibrosis which adversely affect cochlear health and residual hearing. This preclinical study investigated the implementation of an intra-cochlear flushing protocol for the removal of blood. Methods: Three groups of guinea pigs were studied for 28 days after cochlear implantation; cochlear implant-only (control group); cochlear implant with blood injected into the cochlea (blood group); and cochlear implan..

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University of Melbourne Researchers

Tayla Razmovski Author

Kate Brody Author

Dimitra Stathopoulos Author

Ellie Cho Author

Related Projects (1)

AMELIORATING DELAYED HEARING LOSS AFTER COCHLEAR IMPLANTATION

Natural hearing can be combined with a cochlear implant to improve sound quality and speech understanding. However, natural hearing frequent..

Grants

Awarded by National Health and Medical Research Council (Australia)

Funding Acknowledgements

The authors would like to thank Helen Feng for electrode manufacture. This work was funded by the National Health and Medical Research Council (Australia; GNT1125970) and the Garnett Passe and Rodney Williams Memorial Foundation.